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To our shareholders and investors,

On December 1, 2016, we embarked on a new journey as Kubota Pharmaceutical Holdings Co., Ltd. We are committed to translating innovation into a diverse portfolio of drugs and devices to preserve and restore vision for millions of people worldwide. Acucela Inc., now a wholly owned subsidiary, will continue to identify and develop novel therapeutics to treat and slow the progression of sight-threatening diseases and disorders.

Please visit Kubota Pharmaceutical Holdings website here:

http://www.kubotaholdings.co.jp/en

Spotlight

Acucela Inc. is a clinical-stage ophthalmology company that specializes in identifying and developing novel therapeutics to treat and slow the progression of sight-threatening ophthalmic disorders affecting millions of people worldwide. Learn More